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Abstract #3068

A Comparative Study of Brain Regional T1rho Values of Spontaneously Hypertensive Rat and Wistar Kyoto Rat

Feng Zhao1, Li-Hong Zhang2, Jing Yuan1, Queenie Chan3, David Yew2, Yi-Xiang Wang1

1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2Department of Anatomy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 3Philips Healthcare, Hong Kong

An alternate MRI contrast mechanism, T1rho relaxation, has been suggested as a sensitive biomarker to detect Alzheimer disease and Parkinsons disease in patients. T1rho relaxation in hypertension patients brain is not fully understood. Spontaneously hypertensive rat (SHR) is the model most extensively investigated for evaluating hypertensive brain damage. In this study, we measured the T1rho values in thalamus, hippocampus and cortices of SHR rats and Wistar Kyoto (WKY) control rats at the age of 6-month, and found the T1rho values in these regions of SHR rats were higher than those in WKY rats.

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Keywords

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