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Abstract #3039

Use of Magnetic Resonance Elastography for Monitoring of Hepatic Tumor Radioembolization

Philippe Garteiser1, Arnaud Dieudonne2, 3, Rachida Lebtahi2, Mohamed Abdel-Rehim4, Valerie Vilgrain4, Ralph Sinkus1, Bernard E. Van Beers, 14

1CRB3 U773 Universit Paris Diderot, Sorbonne Paris Cite, INSERM, Paris, 75018, France; 2Service of Nuclear Medicine, Hopital Beaujon, Clichy, France; 3CRB3 U773 Universit Paris Diderot, Sorbonne Paris Cite, INSERM , Paris, 75018, France; 4Service of Radiology, Hopital Beaujon, Clichy, France

The localization of yttrium loaded radioembolization microspheres and the detection of their effects on structural and functional integrity of the tumors remain a challenge. In the present work, the mechanical properties of the glass substrate of the microspheres was exploited in applying MR elastography sequence on a phantom and on a hepatocellular carcinoma patient.

Keywords

accuracy acoustical alter alterations arterial assessment assuming attributed available beads beers blue bremsstrahlung carcinoma carcinomas carried caused cite clinical cohort color combined conditions consequences containing corresponded cubic damage days decrease decreased demonstrating depicted described diameter diffuse direct displayed distinct distributed distribution dose doses elasticity electro environment examination explained exploiting feasibility frequency generated glass gradient greater green hence hepatic heterogeneous hours human identified immediately inclusion independently induce intra isotropic known life like liver lobe localization magnitude material matrix mechanical mechanically modulus monitoring motion much necrosis nuclear occupying parametric part patient patients perfusion periodic phantom phys placed post potential prepared presence processing proof properties property protocol radiation radiations radiology rationale referred resolution responses revealed scale sensitized service several shear short solid spatial spent sphere spheres spin square stiffness suboptimal suspension system table tentatively text therapy tissue tracer treated treatment tumor underwent uptake validation viscosity visualize volume wall wavelengths whereas whose yielding yttrium zonal