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Abstract #3015

Ex Vivo MR Imaging; a High Throughput Approach for Characterization of Melanoma Brain Metastases Mouse Models

Amr Morsi1, 2, Avital Gaziel3, Hana Baig1, John G. Golfinos4, Eva Hernando-Monge3, Youssef Zaim Wadghiri5

1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Neurosurgery, NYU Langone Medical Center, NY, United States; 3Pathology, NYU Langone Medical Center, New York, NY, United States; 4Neurosurgery, NYU Langone Medical Center, New York, NY, United States; 5Radiology, NYU School of Medicine, New York, NY, United States

95% of patients with melanoma brain metastases (B-Mets) succumb to their disease within six months of diagnosis. The scarcity of physiologically relevant in vivo models and an accurate non-invasive modality to monitor tumorigenesis hinders the investigation of melanoma brain tropism, and response to therapies. We used ex vivo MRI to characterize the tumor growth in large cohorts of B16F10 and 5B1 melanoma (B-Mets) mouse models. ex vivo imaging proved to be a high throughput imaging modality. Data reveals significant changes in growth pattern between both models and suggests that the 5B1 model is more reliable and relevant for preclinical studies.

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Keywords

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