Meeting Banner
Abstract #2997

Registration of In-Vivo Prostate MRI and Pseudo Whole Mount Histology Using Local Affine Transformation with Internal Structures (LATIS)

Chaitanya Kalavagunta1, Xiangmin Zhou1, Jonathan C. Henriksen2, Stephen Schmechel2, Gregory J. Metzger1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States

In this study we register in-vivo prostate MR with Pseudo Whole Mount histological sections by a non-rigid registration method using local affine transformation guided by internal structures.

Keywords

accuracy accurate acquisition addition addressed affine aggressiveness among anatomic annotated application array artifacts assessing assessment automated available axes better biopsy boundary brain cancer capable cascading chosen coil combined control controls correlation deaths deformable deformation described determined differentiating digital digitize digitized discontinuities distance distortions done downscaled earlier easily eight embedded enable excised experienced extent extracted feature features formalin funding future generated give handle house identical identified identify important improved in vivo inspection internal involve issues laboratory landmarks least local magnitude manually many maps masks matrix metabolic methodology modalities modality mount mounts novel oval paraffin parametric pathology phys pixel plate positions problems processing prostate prostates providing pseudo quarter quarters reduce registered registering registration reliably resolution rigid sample scanner screen section sectioned sections shrinking slides software source spline square stained step steps stitching structure structures studies subjective susceptibility tablet target thin tissue transformation transformed translations tumor tumors uniquely validate validation visible vista visual whole woods yield