Meeting Banner
Abstract #2971

Relationship Between Cell Turnover and Density in Normal Prostate Regions: Correlating Quantified Choline and Citrate with Apparent Diffusion Coefficient from High Resolution DWI

Meer Basharat1, Maysam Jafar1, Nandita deSouza1, Geoffrey Payne1

1CRUK & EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom

2D-CSI using short-TE (TE=32ms) PRESS was performed on 13 prostate cancer patients to assess improved visualisation of metabolite signals with reduced T2-decay compared to the standard TE=100ms implementation and to correlate these metabolite concentrations to ADC. Citrate T2 was 8834ms in the PZ (n=34) and 9050ms (n=86) in the CG, whilst choline T2 was 6118ms (n=13) across both zones, suggesting that short-TE is more favourable for detecting prostate metabolites. Indeed, more metabolites with improved signal were observed using TE=32ms. Citrate-ADC correlation was r2=0.146 which may be due to increase ductal volume in the secretory glandular tissues.

Keywords

absolute accommodating accomplished additional although apparent array attributed basis best cancer cell central chemical choline citrate clinical coefficient coil combination computed concentration concentrations considerably contain corrections correlated correlating correlation decay decays density depiction derived detection determine diffusion distinguish either equivalent established evaluation evolution examinations examined example experienced exponential fits fitted fitting gland glandular healthy height ignoring implementations improved in vivo increasing independently indicate indicative inflated inner inspected institute investigated kingdom larger literature long made malignant matrix medical metabolite metabolites mono observer outer overlap overview partial partly patients peak peaks peripheral plots poorly positive press previous prostate quantification quantified quest reconstruction reduced reducing reduction referred relate relationship resolution respectively rest scanner secretory sensitivity separated sets short shorter shot simulated simulations singlet singlets software spectra spectral spectroscopic spectroscopy suggest suppressed suppression surface surrey systems table tissue tissues turnover variable volume water weak whilst zone zones