Meeting Banner
Abstract #2965

Multiparametric MRI Imaging in Patients Undergoing Ultra-Hypofractionated Radiotherapy for Localised Prostate Cancer

Kent Yip1, N. Jane Taylor2, J James Stirling2, Ian C. Simcock2, Uma Patel1, Nihal Shah1, Peter Ostler1, James A. d'Arcy3, David J. Collins3, Peter J. Hoskin

1Marie Curie Research Wing, Mount Vernon Cancer Centre, Northwood, Middlesex HA6 2RN, United Kingdom; 2Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom; 3CRUK-EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey SM2 5PT, United Kingdom

The use of doses much higher than the conventional 2Gy/fraction during stereotoactic radiotherapy (SBRT) has allowed radiotherapy courses to be significantly shortened from weeks to days. It is increasingly being used in the treatment of localised prostate cancer. From a radiobiology perspective, the lack of time for re-oxygenation to take place during the much shortened duration of treatment may compromise its effectiveness. In this study, based on data obtained from functional MRI imaging, we have shown that there is a significant degree of re-oxygenation in the irradiated prostate during SBRT, and that this is accompanied by transient prostate gland hypervascularity.

Abstract PDF

Keywords

acquisition advances adversely allowed among androgen arbitrary assessed back bespoke blood body calculations cancer clinical cohort commencement common completed completing completion compromise confirm constant continued continues contrast conventionally course curie curve days decrease decreased delivered delivery deprivation disadvantage dose doses dynamic effectiveness enabled enhanced extreme fall feasibility field fifth findings five flow fraction fractionated fractionation fractions gadolinium gland gray hospital hypo hypoxia immediately important increasing increasingly induced influence initial institute insufficient intrinsic kinetic kingdom larger materials matrix months mount much need needed occurs oncologist oncologists outcome oxygenation packages parametric patient patients pattern percentage peter placements practice prior process prostate quickly radiation radiotherapy rather receiving recruited relation remained remains rise role rose safely scanner schedules serial shah sharply shortened sites slices software start suggests surrey susceptibility system table target technological termed theoretical therapy third transfer treat treated treatment turn ultra undergo undergoing units vascular vibe view volume weeks whilst whole wing workbench