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Abstract #2914

Non-Invasive Quantification of Absolute Cerebral Blood Volume Applicable to the Whole Human Brain

Pelin Aksit Ciris1, Maolin Qiu1, Robert Todd Constable1

1Yale University, New Haven, CT, United States

CBV changes occur across diverse pathologies and during functional challenges, however, measurements have been invasive and difficult especially in humans. In this study, whole brain absolute CBV (mL blood/100mL parenchyma) was measured non-invasively in 13 human volunteers during visual stimulation; by further developing a method based on a biophysical model with rotating multi-slice acquisitions maintaining steady state. Such non-invasive quantification could foster improved understanding of the relationship between neuronal activity, hemodynamic changes and metabolism underlying fMRI signal, provide a reference for calibrated fMRI, and potentially find clinical utility in evaluating vascular state, vascular damage, and/or monitoring treatments.

Keywords

absolute acquisition activation active activity allowed applicable approximately arterial arteriolar artery ascending balanced bilateral biophysical blocks blood bolus brain building cerebral challenges checkerboard coil compartment compartments completion composite conditions confirmed considering consistent consisting containing contributions controls cortical coverage covering crusher densities depicted described desirable determines disease diverse done drift enable enabled error errors excitation expanded experience extend extended final fissure fits fitted fitting five fractions gradient gradients gray head healthy human humans important individual inefficiencies interleaved invasive inversion investigating lobe lobes location longest longitudinal magnetization micro model moderate monitoring motion moving neural nulling occipital paradigms pathological pathologies period permitted physiologically pond portion posterior potential previously processed produced proposed proton providing quantification rather regulation relies reported requires response rest resting rotation sample saturation secondly separately settling simulated slice slices space spatial spatially spins spoiler steady stimulus studies tissue tracking transit transition transverse trio upon vary varying versus visual volunteer volunteers whether whole