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Abstract #2895

Group Differences in Brain Activity Between Dyslexic Children and Normal Controls Using Functional Magnetic Resonance Imaging

Youngseob Seo1, 2, Zhiyue J. Wang1, 2, Srinivas Rachakonda3, Jonathan M. Chia4, Nancy K. Rollins1, 2

1Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States; 2Radiology, Children's Medical Center Dallas, Dallas, TX, United States; 3University of New Mexico; 4Philips Healthcare

Dyslexia is referred to as specific reading disability/retardation in spite of conventional instruction and adequate intelligence. Learning to read is one of the most important skills for children to acquire in early education. We compared brain activities between dyslexic children and normal controls for reading and action-related tasks using fMRI and group ICA. We demonstrated there are differences in brain function activities in visual, executive, auditory, motor, sensory cortexes and Brocas area between the 2 groups.

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Keywords

action activation activations activities activity adequate allow analyzed anatomical anterior approved auditory automatic bilaterally block brain button channel children clusters coil color compliant component components concatenation contrast control controls coordinate corrected corrections cortex described description design despite developmental dimensionality direct disability done driven dyslexia dyslexic early education england error estimation evaluated example executive family findings frontal function functional gender general gift grades hand handed head health held important independent indicator individual inference inferior institute instructed instruction intelligence interleaved intervals investigation journal kernel length letter letters lobe make matched materials matrix medical middle motion motor neurological normalized occipital paradigm parietal participants patients population posterior presentation processing radiology read reading referred registered related remarkable reported represents resolution rest retardation sample score secondary sensory several skill slice smoothed software southwestern space spatial spatially speaking stimulus subject subjects summarized summary superior systems table tall task tasks temporal threshold toolbox uncorrected underwent visual whole wise years