Meeting Banner
Abstract #2883

Arterial Cerebral Blood Volume (CBVa) Weighted Functional MRI Using Pseudocontinuous Arterial Spin Labeling

Hesamoddin Jahanian1, 2, Scott Peltier1, 2, Douglas C. Noll1, 2, Luis Hernandez-Garcia1, 2

1Functional MRI Laboratory, University of Michigan, Ann Arbor, MI, United States; 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

Functional magnetic resonance imaging using physiological parameters such as cerebral blood perfusion or cerebral blood volume (CBV), unlike BOLD fMRI, provides a quantifiable contrast and is also more closely related to neural activity. Current Perfusion-based fMRI techniques, however, suffer from poor sensitivity and low temporal resolution. It has recently been shown that the change in CBV during neural activation mainly originates from arterial rather than venous blood volume, but CBV-based fMRI methods (such as VASO and MOTIVE) are also limited by their low signal to noise ratio. We propose a novel method based on pseudocontinuous arterial spin labeling (pCASL) technique to achieve a contrast that depends on arterial cerebral blood volume (CBVa) and can be used for functional imaging experiments. The method proposed here offers sensitivity to brain activation that is on par with BOLD imaging and superior to perfusion ASL, while maintaining most of the advantages of perfusion ASL imaging.

Abstract PDF E-Poster Video

Keywords

accommodate achieve acquisition activated activation adjusted advantages allow although analyzed arbor arterial bars best blood blue bold brain bulk cerebral checkerboard chose closely closer collected collection compartment condition considering contrast contribution contributions control correcting cortices crossing crusher crushers dashed delay desired determine determined duration employed engineering errors estimation excite exists expected experiment field find five flashing flow functional general gradients home identify increasing indicate indicated keeping labeling laboratory largest location mainly maintaining maps minus model motor neural next noise novel null offers opposition optimal originates outperformed pair paradigm perfusion physiological poor post preliminary presence proportional propose proposed providing pulses quantifiable rather recently reconstructed related resolution resources respectively rest resting retaining scanned scanner score selection sensitivity sequential several shared simulated simulation simulations simultaneous slice software spin spiral statistical subject subjects subtracted suffer suggest suggested suitable superior suppressed tagged tagging task temporal timing tissue transit unlike usually varying venous visual volume yielded zero