Meeting Banner
Abstract #2872

Disruption of Interhemispheric Functional Connectivity by Peripheral Nerve Block

Todd B. Harshbarger1, M. Stephen Melton2, Allen W. Song1, Stephen Klein2

1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States; 2Anesthesiology, Duke University Medical Center, Durham, NC, United States

Functional connectivity is increasingly used to compare normal brain states with various disorders. In this study, we investigated resting state functional connectivity before and after a peripheral nerve block. We show that cross-hemispheric correlations in motor areas which exist before the block is applied are disrupted by the nerve block. These correlations return immediately after the block wears off. This can have implications in the study of connectivity and correlations between hemispheres, as well as potential implications for studies of how the brain reacts to damage in the peripheral nervous system.

Keywords

actual administered allow although analyzed anesthesiology applied aspiration become began better bicarbonate block blockade bottom brain channel clear coil combined common connectivity consent consisted correction correlation correlations cortex cross damage define defined described determine determined determining disease disorders displays disrupted disruption duke easily electrocardiogram elevated ended entire epinephrine extent eyes fixation full functional generated greatly guided handed head healthy hemisphere hemispheres hours human imagined immediate included increasingly incrementally individual induce instructed larger least maintain maps matrix measures medical monitors motion motor negative nerve nervous open part participated peripheral place placed plasticity post pressure previous primary prior processed produced produces producing rats recently reduced remain removed represent resting returning reversible role routine scanner scores screen seed sense sensory separately series session sessions side significantly slice slightly sodium solution song spiral still strength strong studies subject subjects submitted supine supplying system tapping tasks temporary third threshold timing topic turned ultrasound underwent ways whole