Meeting Banner
Abstract #2868

Reduced Local BOLD Correlation in Pre-Frontal Cortex During Deep Sleep

Xiao Liu1, Silvina G. Horovitz1, 2, Allen R. Braun3, Walter S. Carr4, Dante Picchionie5, Masaki Fukunaga1, Jeff H. Duyn1

1Advanced MRI section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States; 2Human Motor Control Section, MNB, National Institutes of Health; 3Language Section, Voice, Speech and Language Branch, NIDCD, National Institutes of Health; 4Naval Medical Research Center; 5Department of Behavioral Biology, Walter Reed Army Institute of Research

In this study, the average temporal correlation of spontaneous BOLD fMRI activity within local brain regions was computed and compared between the wake and slow wave sleep (SWS) stages in human. Significant reductions in local BOLD correlation were primarily found in the prefrontal cortex during the SWS, while increases were limited to posterior brain regions. The finding is consistent with the notion that prefontal activity is an important constituent of higher cognitive function during conscious awareness, and the fact that the latter is reduced during SWS. This suggests that the distribution of local correlation may report on cognitive state.

Keywords

absence according alter altered amplitude angular anterior appear army aspect atlas avoiding band bars behavioral biology bold brain brains briefly called carefully central certain coefficients cognitive coherence collected comparatively condition conditions connectivity consciousness consistent containing control corrected correlation correlations cortex cortical courses deal decrease deep deprivation deprived described deviation distinct divided dominated either equal error exclusive explicit extend filtering fluctuation focus focused frontal function generate head health include index indicate inferior institutes insular inter investigate language light local locate long manner maps marked medial medical middle motion motor national nature naval networks notion occipital oxford pair pars part pass pattern patterns period periods pole posterior processed quantify quantifying random reduced reed reflect regional relatively reside resting reveal reveals role section segment segments selected separately short significance significantly sleep slow smoothing spatial spatially speech spontaneous stage star stars studies subject subjects summarized superior supplemental supplementary tasks template temporal variation voice wake wave