Meeting Banner
Abstract #2839

Microvascular GE BOLD Specificity and Dynamics Revealed by Ultra High Field MRI in Humans

MAGNA25Jeroen C. W. Siero1, 2, Nick F. Ramsey1, Hans Hoogduin1, 2, Dennis W. J. Klomp2, Peter R. Luijten2, Natalia Petridou1, 2

1Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Gradient-echo BOLD at high fields has opened up the possibility to visualize the cortical columnar and laminar functional organization but its specificity can suffer from contributions of several vessel sizes even at high fields. Here we assess the microvascular contributions of the GE BOLD response (HRF) across the cortical depth at 7T by relating it to the microvascular specific SE BOLD response. We show that the early phase (onset time and rising slope) of the GE HRF is specific to the microvasculature in deep gray matter which presumably contains layers III-V.

Abstract PDF E-Poster Video

Keywords

active analyzed anatomical anatomy black blood bold caused channel checkerboard close closely cluster coil columnar combination comparing computed computing consisted contains contour contributions coronal corrected cortex cortical coupling deconvolution deep defined delineated delineation depth depths design direct directly distance dividing done dotted draining duration dynamics earlier early error estimation event evolution excluded exponential field fields find fitting flatter flow fold full functional funded generated gray green humans ideally identical important impulse indicate institute intercept interpolation isotropic laminar largest length local localizer manually maps match matches measured mechanisms medical meeting much neural neuronal normalization observable onset opened overlaid paradigm part parts peak percent period periods plus pooling possibility potentially processed processing radiology readout recently recorded related representative resolution resolved respiratory response reveal revealed rising scientific sections selected sensitive several shaded short shot sites slope specificity spin stimuli stimulus subject subjects suffer surface system temporal threshold tissue ultra uniformly veins visualize white width