Meeting Banner
Abstract #2837

Dynamic Compartment-Specific Cerebral Blood Volume and BOLD Responses to Electrical Forepaw Stimulation in α-Chloralose Anesthetized Rats

Xiaopeng Zong1, Tae Kim1, Seong-Gi Kim1

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Studying the compartment-specific dynamic cerebral blood volume responses is important for quantitative fMRI studies and understanding the dynamic properties of BOLD fMRI responses. In this study, we measured BOLD, arterial (ΔCBVa), venous (ΔCBVv), and total cerebral blood volume responses to electrical forepaw stimulation in α-chloralose anesthetized rats using a magnetization transfer-varied fMRI technique and injection of paramagnetic contrast agent. We found a fast ΔCBVa response and a delayed slower ΔCBVv response. Our findings are consistent with earlier studies under different anesthesia conditions and support the anesthesia independence of the fast CBVa and slow CBVv dynamic properties.

Keywords

accomplished achieve acquisition activation adjusted agent agree amplitude amplitudes anesthesia anesthetic anesthetized animal animals applied approved arterial assumed assuming averaging black blood body bold boxcar boxes calculation cats cerebral clearly coil compartment condition conditions consecutive consistent consists console constant constants contrast convoluted convolution coronal correcting cortex course courses decreased delay delays denotes determined diameter dilation direct displayed dominantly dominated drew duration dynamic dynamics earlier electrical except experiment exponential fast findings fits fitted flow free functional general gradient horizontal important impulse induced initial injection inset intensities intercept interfaced investigate known least long magnet magnetization maps matrix models much multiplying normalized offset onset optical overlaid partition period periods pharmaceuticals physiology planar post power previous primary prolonged properties pulses quantitative radiology rapid rats recovered relatively respectively response responses several since slice slower square stimulation stimulus studies subtracting support surface thick tissue transfer treating trial uncertainty understanding varied venous versus vessel vessels volume weighing zero