Meeting Banner
Abstract #2834

The Contribution of Vascular Reactivity in Layer-Specific Hemodynamic Response

Cecil Chern-Chyi Yen1, Fuqiang Zhao2, Seong-Gi Kim3, 4

1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; 2Imaging, Merck, West Point, PA, United States; 3Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 4Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States

Cortical layer-specific responses are shown to resemble the neural response of the cortical layers. However, these layer-specific hemodynamic responses may be contaminated by the vascular reactivity, which is known to have layer-specific distribution. To investigate this issue, we performed two cerebral blood volume (CBV)- weighted fMRI studies in cat visual cortex with hypercapnic stimulus as an indicator for vascular reactivity, and visual stimulus. Our results showed that the peak responses of the CBV-weighted layer profile induced by hypercapnic stimulus co-localized with that induced by visual stimulus. Therefore, cautions shall be taken in interpreting layer-specific hemodynamic response as neural response.

Abstract PDF E-Poster Video

Keywords

access acknowledgments activation activity addition administrated affects altering alto animal animals approved believed bioengineering bolus boundary built carbon care cats caution cerebral challenge coil committee comparing consisted contour contribution cortex cortical coupled custom degree delineated depth determined dilator dimension dioxide disorders distance elicited error examine excessive frequency funded general generating grants gray green health horizontal hospital ignored indicating induced inside insightful institute institutes institutional inter interpolated intravenously investigate laminar layer layers linear localized magnet maps masked matrix measured mechanically middle mixture national nature neural neurons normalized outside paradigm part peak peaked percentage ping placed preparation primary proceeding processing profile profiles protocol quadrangular questions radiology raised reactivity recent reflecting reports represents resolution response responses role sampling scale segment sensory shape shot slice solution spatial spatially spite square stimulate stimulation stimulus stroke strong studies subject support surface taken temporal thank tidal tightly underlying vascular ventilated vessel visual volume wave weighing west whether zero