Meeting Banner
Abstract #2568

A Model-Based Method for Registration of ex vivo to in vivo Prostate MRI Using Elastography

Guy Nir1, Ramin S. Sahebjavaher1, Piotr Kozlowski2, Ralph Sinkus3, Septimiu E. Salcudean1

1Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada; 2MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; 3Centre de Recherche Biomdicale Bichat-Beaujon (CRB3), Paris, France

We propose a novel method for registration of an ex vivo 3D model of a prostate to an in vivo MRI volumetric image. Such method may be employed to generate probability maps for prostate cancer distribution. The in vivo scan is followed by an MR elastography scan, from which the true elasticity parameters can be extracted and assigned to each voxel of the in vivo image. This allows a realistic regularization of a non-rigid registration method in order for it to produce physical and accurate deformation maps. Experiments on both synthetic and clinical data show promising results.

Abstract PDF Poster PDF

Keywords

accurate actual align aligned allow allows application applied approved arbitrary around assigned assigns best blends board build cancer challenge clinical coefficient constant constraints constructed contain correlate cross cyan date deformation deformed develop dice distribution dynamic early easily elasticity employ engineering ensures entire ethics fashion field fixed forces formalin generated gland global goal histology illustrated in vivo inaccurate incorporation initial initially inside institutional inverse iterative knowledge local manner manual mapping maps match measured medical mined misalign model models needed next noon notice novel onto optimized outside overlaid overlap oxford parametric patient performance physical post press probability process produce promising properties propose prostate quality radical rather realistic registered registration regularization remains reported residual respect rigid rigidly rotates rotations scales scanned scheme science sections segmentations segmented signed slice slices specimen step surface synthetic system tissue trans translates translations unknown utilizes variations vibrations view volume volumetric warp warped ween