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Abstract #2521

3D MR Elastography of In-Vivo Prostate Cancer and Correlation with Histology: Preliminary Results

Ramin Sahebjavaher1, 2, Philippe Garteiser2, Ralph Sinkus2, Louis O. Gagnon3, Ali Baghani1, Silvia Chang3, Simon Chatelin2, Edward C. Jones4, Chris Nguan3, Larry Goldenberg3, Piortr Kozlowski5, 6, Mehdi Moradi7, Septimiu Salcudean1

1Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada; 2Hpital Beaujon, Centre de Recherche Biomdicale Bichat Beaujon (CRB3), Paris, France; 3Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; 4Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; 5Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; 6The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada; 7Department of Radiology, Harvard Medical School, Cambridge, MA, United States

We present our first in-vivo prostate cancer case using the trans-perineal MR elastography (MRE) method. An improved rapid imaging sequence is used to acquire waves in 3D in the entire prostate gland. The mechanical waves efficiently transferred to the entire prostate via the perineum at 70Hz. The results show that the tumours are clearly distinguishable in the viscoelastic maps and that they correlate closely with histopathology. To the best of our knowledge, this is the first in-vivo prostate cancer MRE study where the viscoelastic maps are compared to whole-mount histopathology. These results show the potential for MRE to improve staging of prostate cancer tumours.

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Keywords

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