Meeting Banner
Abstract #2516

Repeatability of Healthy Subjects Using Intrinsically-Activated MR Elastography

Adam J. Pattison1, Matthew DJ McGarry1, John B. Weaver1, 2, Keith D. Paulsen1, 3

1Thayer School of Engineering, Dartmouth College, Hanover, NH, United States; 2Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States; 3Norris Cotton Cancer Center, Lebanon, NH, United States

Intrinsically-activated MR elastography has been shown to give reasonable results for brain tissue and detect differences between normal and hydrocephalic patients. However, natural changes in metabolism and blood pressure over time can change the mechanical property signature of a healthy subject. The aim here is to see if intrinsic activation is sensitive to changes in a healthy subject over time and, also, sensitive to changes amongst a healthy population. Results indicate that this technique detects a slightly larger mechanical property variation over time and has a much smaller variation for a single subject than among a group of healthy subjects.

Abstract PDF Poster PDF

Keywords

ability activated activation actuated addition altered among applications array brain brief cancer card certain college comparing consistent consistently contrast controls coronal cotton cycle days deformation described detection dies disease displacements divergence elucidates extract field fluid fractional giving healthy heart hods hydrocephalus hypothesis in vivo intrinsic john know look mall measure measured medical modulus motion much natural natures need negate part patients placement popular pore pressure previous processed properties property recently reconstructions repeat repeatability repeatable repeated saturated scanned scanner school separate series serves sessions shear sign slice slight smaller source stays structures stud studies subject subjects taken theorem tissue tissues transactions variability variation varied velocity versus view went whereas wide