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Abstract #2514

Assessment of Stiffness Changes in the ex vivo Porcine Aortic Wall Using Magnetic Resonance Elastography

Lei Xu1, 2, Jun Chen3, Meng Yin3, Kevin J. Glaser3, Qingshan Chen4, David A. Woodrum3, Richard L. Ehman3

1Radiology Department, Mayo Clinic, Rochester, MN, United States; 2Radiology Department , Beijing Anzhen Hospital, Capital Medical University, Beijing, China; 3Radiology Department , Mayo Clinic, Rochester, MN, United States; 4Orthopedics Biomechanics Lab, Mayo Clinic

MRE is a noninvasive phase-contrast technique for estimating the mechanical properties of tissues. In this study, we hypothesize that changes in arterial wall stiffness, experimentally induced by formalin fixation, can be measured using MRE in ex vivo porcine aortas. In agreement with our hypothesis, the significant stiffness increase after sample fixation were clearly demonstrated by MRE and confirmed by mechanical testing. The results indicate that MRE can be used to examine the stiffness changes of the aorta. This study has provided evidence of the effectiveness of using MRE to directly assess the stiffness change in aortic wall.

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Keywords

aorta aortas aortic applied arterial artery assess bottom buffered capital channel china clinic coil comp consequences directly driver dynamic elastic emerged established estimating explained five fixed fluid formalin fresh generate gradient highly hospital hypertensive in vivo induced initial intervention invasion linear major mayo measure measured measuring mechanical mechanics medical mentally models moduli modulus much near neutral offer pared people poorly porcine potential prior produced propagating properties protocol pursue radio receive republic respectively revealed risk saline sample samples specimens stiffen stiffness stroke structure student studies target tensile tissue understood upper various vessel visualized wall walls wave wavelength waves young