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Abstract #2465

Adaptive Respiratory Triggering for High Spatial and Temporal Resolution 3D DCE-MRI in the Mouse.

Alexandr Khrapichev1, Veerle Kersemans1, Danny Allen1, Sean Smart1

1Oxford University, Oxford, Oxfordshire, United Kingdom

A method for performing high temporal and spatial resolution imaging for DCE-MRI in the mouse is presented. Respiration triggering is used to reduce motion artefact, and dummy scans are used to regenerate the T1 steady state following each breath. Both the rate and depth of the breathing change over the duration of a typical DCE-MRI scan so the numbers of dummy and imaging acquisitions per breath may need to vary in order to maximise data capture rate whilst avoiding motion. 3D gradient echo scans with an isotropic resolution of ca. 400 micron and a temporal resolution of 5 s (untriggered) and 8-9 s (triggered) is achieved. Respiratory gated and non gated scans of the mouse abdomen and thorax were acquired sequentially during the uptake from a single bolus injection of Gd contrast agent. Improvements to signal-to-noise and image fidelity are shown when using triggering.

Keywords

abdomen absence acceptable accommodate according achieve achieved acquisition acquisitions adaptive agent agents allows anatomical aorta assist balloon benefit birdcage block body bolus breath breaths clearly clinical coil collection combination comparing contrast controlled correctly cost covered delivery demonstration dependent depth describe development diaphragm directly dummy duration dynamic examination excursion fast feature features gated gating generates generator gradient heart hiatus highlight homogeneous identifiable improve improved independently induces initial instantaneous interfaced interleaved interleaving isotropic kidney kinetics kingdom labels largely latency leading liver long lungs made maps matrix measured mice motion mouse movement necessarily next noise nominal occurs outweigh oxford pair pairs particular penalty pixel place pressure pulsation pulses quadrature quality rapid rather real recognized reduction regeneration related replace resolution resolutions respiration respiratory response running scanning selectable selection separate simply slice smart spaced spatial spoiling steady successfully takes temporal though timestamps tissue tissues trigger triggered triggering unit upon uptake user validation variable volume volumetric washes