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Abstract #2186

Cerebral Blood Volume Changes During Brain Activation

Steffen Norbert Krieger1, Robert Trampel1, Markus Streicher1, Robert Turner1

1Neurophysics, Max Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Saxonia, Germany

Due to its good localization to neuronal activity, fMRI studies have begun to utilize changes of cerebral blood volume (CBV). However, if cerebral vessels are considered to be impermeable, the contents of the skull incompressible, and the skull itself inextensible, task-related and hypercapnia-related changes of CBV could produce intolerable changes of intracranial pressure. We propose that much of the change in CBV is facilitated by exchange of water between capillaries and surrounding tissue. To explore this idea we developed a novel hemodynamic boundary-value model and found approximate solutions. A macroscopic experimental model provides biophysical insight.

Keywords

account activation activity address allowed among approaches approximate arterial axis back balloon begun better biophysical blood bold boundary brain capillaries capillary cavity cerebral channels comparable compartment concept conceptual conditions consistent constant constants constructed continuity continuous contributors cranium dangerously decreased decreases developed diameter differential distributions doctrine drop elastic elevated entailing equations equilibrium exchange expand expense experiment experimental explore facilitated finite flow fluid gave highly hypothesis idea impermeable importance important in vivo increasing inflow initial input inside insight instance intolerable issues length literature localization macroscopic made marker measured microscopic middle minimize model modeling models moved negative neuronal nonlinear novel nozzles numerical optical origins perforated permeability permeable permeated physiological plank poorly pressure pressures processes properties putting quantify radius realistic received recognized recordings regarding remain reservoir response rigid roughly running sciences section simulate simulated simulation situation slow solutions split stage starling static stokes studies surrounding theoretical thin tissue took usually utilize velocity venous vessels volume wall water