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Abstract #2162

fMRI/fcMRI Investigation Showing Cortical and Subcortical Pathways Involving in Phrenic Nerve Activation and Respiration Control in Rats Under 9.4Tesla.

Rupeng Li1, Nicholas Flugstad2, Xiping Liu3, Christopher Pawela1, 2, Ji-Geng Yan2, Hani S. Matloub2, James S. Hyde1

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 3Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States

Cortical and subcortical pathways accouting for phrenic nerve function were discovered with the combination of BOLD fMRI and fcMRI for the first time.It helps with further investigation of respiratory system control and provide physiological basis for this nerve to be used as donor for peripheral nerve injury repair.

Keywords

account achieved activation animal animals applications applied ates avoid biophysics block blood bold brain bromide catheter chosen clear clearly clinical clinically close college contrary control cortex cortical davenport demand design done donor electrical electrode emphasized example exposed femoral filter fires function functions good grad great highly humans incubation individual infused interestingly involved known leads leaving localized locates maintained major medical meters monitored motor nation needs neither nerve nerves network note occurs onto owing oxygen pass past pathways patients physiological ping placed plastic pons preparation previous rats refined regain related remain reported respiration resting revealed role roots scanned scanner seed sensory side slice slices spatially stem stimulated stimulation studied surgery surgical system transfer transform trunk underling upper varies venous ventilator yields