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Abstract #2132

Greater Activation of Brain Regions Serving Abstract Reasoning Abilities in Alcohol Dependents: An FMRI Study

Deepika Bagga1, Namita Singh1, Shilpi Modi1, Mohan Lal Garg2, Debajyoti Bhattacharyya3, Prabhjot Kaur1, Subash Khushu1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi, India; 2Department of Biophysics, Punjab University, Chandigarh, Punjab, India; 3Base Hospital, Army Medical Corps, Delhi, India

Neuropsychological findings suggest a deficit in abstract reasoning abilities in alcohol dependents. However, this deficit has not been studied so far using BOLD fMRI. We attempted to address this issue by carrying out an fMRI study on alcohol dependents and controls for an abstract reasoning task. Alcoholics showed a greater activation in the fronto-parieto-temporal network implicated in abstract reasoning suggesting a compensatory mechanism to meet the task performance comparable to controls.

Keywords

ability abstinent abstract activation active activity alcoholics allied analogy anatomical applied army assess assessed ates attention attributed attributes autism aversion better biophysics body bold brain carried chosen chronic cluster cognitive coil combining compensatory complex concepts connected control controls corps correction cortex days deep deficit device distinct duration education eliminating enhanced equal executive extent false features field finding fink fixation form frontal functioning give gradient greater handedness hardware head healthy help hospital identify impairments implicated implies index inferior initial institute integration interleaved laird learning lobule location making maps matrix mechanism medical middle month months neck network neural noise object objects oblique parietal part passed patient peak performance post processing question questions radius reason reasoning recognize related rendered resp response risk rogers sample saturation sciences sequential series serving since software spectrum stimuli stream stud subjects superior system table task temp temporal thought threshold toolbox unctions understand various verb view visual volumes west whole