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Abstract #2118

Anterior-Posterior Dissociation of the Default Mode Network in Dogs

Sreenath Pruthviraj Kyathanahally1, Oleg Mykolajovych Pustovyy2, Paul Waggoner3, Ronald Beyers1, John Schumacher4, Jay Barrett5, Edward E. Morrison2, Robert L. Gillette4, Thomas S. Denney1, 6, Vitaly J. Vodyanoy5, Gopikrishna Deshpande1, 6

1AU MRI Research center,Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; 2Department of Anatomy,Physiology & Pharmacology, Auburn University, Auburn, AL, United States; 3 Canine Detection Research Institute, Auburn University, Auburn, AL, United States; 4Department of Clinical Sciences, Auburn University, Auburn, AL, United States; 5College of Veterinary Medicine, Auburn University, Auburn, AL, United States; 6Department of Psychology, Auburn University, Auburn, AL, United States

The Default mode network (DMN) has been observed in humans and monkeys, but not in rodents. In order to investigate the evolutionary hierarchy of the DMN, we obtained resting state fMRI data in dogs and performed independent component analysis (ICA). Dogs, being lower than humans/monkeys, but higher than rodents in evolution, showed localized correlations in the posterior cingulate region in one ICA component while in the medial frontal regions in another ICA component. This shows that there is anterior-posterior dissociation and localized synchrony in DMN in dogs, which is a strikingly similar result to the one obtained in young children.

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