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Abstract #2114

Altered Baseline Oxygenation and Blood Flow Perturb Resting-State Functional Connectivity a Nonhuman Primate Study

Hsiao-Ying Wey1, 2, Jinqi Li2, Timothy Q. Duong, 23

1Department of Radiology, A. A. Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Charlestown, MA, United States; 2Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 3Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Recent advances in resting-state functional connectivity highlight its potential utility in clinical populations. In this study, we aimed to systematically investigate the effects of different basal oxygenation and blood flow conditions on fc measurements in non-human primate. Our results showed that cerebral connectivity, when compared to normal air condition, was reduced under hypercapnia and hyperoxia but remained comparable under hypoxia. These findings could have strong implications when applying resting-state fMRI in disease states in which baseline oxygenation and blood flow are markedly altered.

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Keywords

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