Meeting Banner
Abstract #2108

Dynamics of Resting-State Functional Connectivity Associated with Heart Rate Variability

Catie Chang1, Coraline D. Metzger2, Gary H. Glover3, Martin Walter4

1Advanced MRI section, NINDS, National Institutes of Health, Bethesda, MD, United States; 2Department of Psychiatry, Otto-von-Guericke University, Magdeburg, Germany; 3Department of Radiology, Stanford University, Stanford, CA, United States; 4Department of Psychiatry, Otto-von-Guericke University,, Magdeburg, Germany

It was previously observed that functional connectivity exhibits dynamic changes over the course of a resting-state fMRI scan. The origins and relevance of such fluctuations, however, are not clear. Here, we examine whether heart rate variability, an index of psycho-physiological state, covaries with changes in the seed-based functional connectivity maps of regions involved in salience processing (dACC, amygdala). Significant effects were found in multiple cortical and subcortical regions, including thalamus, brainstem, basal ganglia, and insula, suggesting that fluctuations in autonomic or emotional processes may constitute one source of spontaneous connectivity variation.

Abstract PDF

Keywords

acknowledgments activity affect afferent afferents aims allow anatomic appear arises association autonomic available basis beat blood brain caffeine cardiac cerebellar certain characterization clear computed conditions confined connectivity control corrected correlation course dependent diameter dorsal dynamic dynamics either entered equilibration examine examined extent eyes fact field flow fluctuations focal force functional glover healthy heart identical identify illustrated implicated included institutes inter interactions intra lane latter linear maps marker martin maximize mediating minutes modulate monitoring much naturally negatively nervous network neural normalized nucleus origins overlap parasympathetic pattern physiological positive potential previous processes processing prospect psychiatry psychological psychophysiology quantifying raising rather regression related relationship reported respiratory responses resting richer routinely salience sample scales section seed seeds significance significantly slice sliding social space spherical spontaneous static statistical strength stress structures studies subject successive system task tasks temporal thalamus threshold trends turn typical typically uncorrected understanding underwent variability vary volumes weaker white whole whose window windows