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Abstract #2106

Optical Imaging of Functional Connectivity in the Mouse Brain

Adam Q. Bauer1, Brian R. White1, Abraham Z. Snyder1, Bradley L. Schlaggar1, Jin-Moo Lee2, Joseph P. Culver1

1Radiology, Washington University in Saint Louis, Saint Louis, MO, United States; 2Neurology, Washington University in Saint Louis, Saint Louis, MO, United States

We combined resting-state functional connectivity mapping with optical intrinsic signal imaging (fcOIS). We demonstrate functional connectivity in mice through highly detailed fcOIS mapping of resting-state networks across most of the cerebral cortex. Synthesis of multiple network connectivity patterns through iterative parcellation and clustering provides a comprehensive map of the functional neuroarchitecture and demonstrates identification of the major functional regions of the mouse cerebral cortex.

Keywords

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