Meeting Banner
Abstract #2099

Correction of Hemodynamic Latency Based on Breath Holding Improves Granger Causality Obtained from FMRI Data

Zhihao Li1, Behnaz Yousefi1, Gopikrishna Deshpande2, 3, Xiaoping Hu1

1Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States; 2Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; 3Psychology, Auburn University, Auburn, AL, United States

Granger causality analysis of fMRI data suffers from spatial variability of the hemodynamic response. The present study attempted to correct this variance by signal latency values derived from breath holding. With fMRI data acquired during face perception, our correction showed improved effective connectivity from the primary visual cortex to the fusiform face area. The present results demonstrated the utility of breath holding based signal latency correction for Granger causality analysis.

Keywords

according accuracy activation adjust adults alliance applied asked assessed assessing auburn axial back beneficial best biomedical bold brain breath calculating causality challenge coefficient coefficients common completed compromised computer confounded connectivity correct corrected correction correlated correlation cortex cortical courses defined derived detected detection determined directional drowsiness effective efficacy electrical engineering examine examining expected face faces feasibility fusiform generally granger grant healthy holding human identified improve improved improves improving indicating influence influences institute inter intervals known larger lasting latency lobe maps matrix memorize minutes much neural neurophysiology occipital outputs participants participated particularly passing pathway perception positive prescription previous primary problem processing psychology random reactivity recordings regional repetitions require resolution respectively response responses resultant runs sample sampled sampling sensitivity series significance simulation slices solution spatial step stimulus studies subject subjects subsequently suggested supported surrogate table technology temporal temporally trans turned unassociated uncorrected unit utility validations vascular ventral version versions visual whose widely wise yellow