Feasibility of Using Simultaneous BOLD-ASL to Estimate the Magnitude of the CBF Response to an Unknown Stimulus

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abstract accurately activation active activity alone applied arising assumed attributable averaging background basic basis behavior benefit bias biasing bioengineering bold brain calculating cerebral challenges characteristic chart clustered comparing complex conditions contribute correlated correlation coupling courses critical cycle defined described despite detection determination determined develop deviation difficult drifts driving dynamic dynamics either eliminates examine experiment experimental exploits expressed feasibility flow fluctuations fraction function general glover goal hypothesized idea identify improves interpreting intrinsic intrinsically investigate investigating issues knowing known linear local locally magnitude meaningful measured metabolic metabolism methodology model networks neural noise onto overcome overestimated oxygen paradigms particular pattern periods physiological previously primarily proceeding projecting projection quantification quantifying quantitative radiology reduced reduces reducing related represented response responses scaled scanner seed selected sense series significantly simultaneous sources space spatially square step stimuli stimulus studies subject subjects suggesting taken temporal tools toward transients true uncorrelated underestimate underestimated underlying unknown variance vector versions visual ways whether