Meeting Banner
Abstract #2010

Combined Measurement of Perfusion and Venous Oxygen Saturation During Reactive Hyperemia in the Leg

Erin K. Englund1, Michael C. Langham2, Cheng Li1, Emile R. Mohler3, Thomas F. Floyd4, Felix W. Wehrli2

1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Cardiology, University of Pennsylvania, Philadelphia, PA, United States; 4Department of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, NY, United States

To make use of the dead time during the post-labeling delay inherent in ASL sequences, a hybrid PASL/MR susceptometry sequence was developed capable of measuring perfusion, a microvascular parameter, and venous oxygen saturation (SvO2), a macrovascular parameter, with 2-second temporal resolution. Repeated measurements of perfusion alone, SvO2 alone, and PASL/SvO2 combined revealed no significant difference between the perfusion measurements (PASL vs. PASL/SvO2), or SvO2 (susceptometry vs. PASL/SvO2). These data suggest that the combined method is capable of quantifying perfusion and oxygen saturation simultaneously, thus providing measures of vascular physiology on both the macrovascular and microvascular level.

Abstract PDF Poster PDF

Keywords

accumulation achieved acquisition acquisitions adiabatic affected agree alone alternating anesthesiology around arterial aspen bars better bioengineering black blue brain brook capability capable cardiology chose coil combined conditions consecutive control courses cuff dataset dead delay detected detection determining deviation diagnosis disease disrupts distal downstream either enter entire error every experimental extremity fair feasible femoral fern flowing grants healthy help hyperemia indicate indicates induced insert interference interleaved inversion investigate keyhole knee labeling labs long made magnetization make mapping matrix measure measured medicine muscle occlusion oxygen paired partial peak perfusion period peripheral physiology pixel post potential prevent produce propose protocol pulse pulsed quantified radiology reactive recent reconstructed recovery release repeated required respectively rest saturation school secured selective sensitivity simultaneous simultaneously singular skeletal slice spin spins spoiled stony student studies subject subjects suggest suggests superior surrounding system table tagged though tissue tourniquet transfer treatment twelve understand upslope vascular vein venous vertical washout years yellow young