Meeting Banner
Abstract #2001

Look-Locker Acquisition for Estimation of Partial Volume Fractions in ASL Data

Jan Petr1, Georg Schramm1, Frank Hofheinz1, Jens Langner1, Jrg Steinbach1, Jrg van den Hoff1

1PET center, Department of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Partial volume correction becomes an important issue in arterial spin labeling. It is usually done using the partial volume maps obtain by segmenting the high resolution T1-weighted images. This brings additional issues with imperfections in segmentation and corrections of image distortion. We propose an alternative by using T1 relaxation times obtained from the Look-Locker sequence to directly obtain the partial volume ratios. These ratios show higher agreement with the perfusion data than the standard T1-weighted images segmentation.

Keywords

absolute accuracy acquisition addition affected aligned alternative always analyzed arterial artifacts assume assumption better blood border brain cerebral clearly clinical closer coil common compensation computed consisted contain control correct corrected correction decreases deformations denoted density depends describing difficult discrepancies distribution done drawback effective equal equations equilibrium error estimation every expected field finally fitting flow fraction fractions frank getting giving gray head healthy hence incorrect indicate induced ingenuity inhomogeneities inversion knowledge label labeling least literature locker longitudinal look looks magnetization make maps mater matrix measured middle mixture model moreover need neighborhood part partial perfusion pixel pixels position precise processing promising proposed protocol qualitative quantification quantified quantify real registration relatively resolution respectively rigid sampling scanner segmentation segmented sense shin significantly slice slices smaller smooth smoothness solving spatial spin square squares strongly structures studies subject subjects supposed susceptibility system thoroughly tissue toolbox types typical uncorrected valid validation variation verify volume volunteers water white yields