Novel Pharmacokinetic Model for Fractional Blood Volume Quantification with the Rapid Steady State T1 MRI Technique in Tumors with Gd-DOTA Permeable Vasculature

Keywords

accordance according acquisition acquisitions adiabatic agents aims allowed amplitude anesthetized approved arterial barrier basal berger biotechnology blood body brain brains cancer cells classification clinical clinically coil collagen combination committee compartment confined confinement constant contrast coronal corroborating days density despite determination developed duration dynamic easy echoes eight employing endothelial enhanced equals equilibrium estimations ethic excitation experiment exponential extended extrapolated fitted flow fraction fractional function gadolinium geometry gradient grading great head histogram histological histology hour illustrates injected injection inoculation input institute institutional intact interval intravenously inversion known laboratories lamina leakage limited maps marked material matrix minute model modeled modeling molecular monitoring mouse normalization normalized novel originally permeability permeable pool post powerful pressure preventing previous prior proton providing quantification radiology rapid rats reaches recovery regional related remain removing representative require routinely scanner scanners selective significantly slice sous southern space staining steady studies surface therapies tissue tissues transmission tumor tumors validated validating vascular vessel volume