Assessment of Uncertainty in the Estimation of Pharmacokinetic Model Parameters for DCE-MRI Data Analysis

Keywords

accuracy accurately added addition additional affected agent arterial assess assessed assessment assumed assumption attributed became become berger best better blue bottom compartment compartmental compartments concentration constant construct contraction contrast cost depending difficult done dotted dynamic enhanced estimation estimations even example exchange expected extracellular extracted extremely find fraction full function gave generated gold good gradient green guess guesses hence improve improved increasing influence inherent initial input intensity inter intracellular introduced investigate investigated iteration iterations lack larger life lifetime limit linear local longitudinal made materials mead measure median medicine minimal minimizing model models next noise noisy nominal numerical numerically observation often optimal optimization overall particularly partly plot plots practice precise precision presence process quantitatively radiology random recently relationship reliably remarkably repeated repeats represent representative requires response scheme school selected selecting sensitive shutter simplex simulated simulation site speed spoiled statistic studies substantially summarized tissue totally trans transfer transient uncertainty unknown vascular volume water worse