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Abstract #1965

Simple Motion Correction for Hepatic DCE-MRI: Registration of Sequential Breath Holds in 3D Radial Time-Resolved Scans

Eric Bultman1, Debra Horng2, Ethan K. Brodsky2, Kevin M. Johnson2, Walter F. Block1, 2, Scott B. Reeder1, 3

1Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 3Radiology, University of Wisconsin-Madison, Madison, WI, United States

Quantitative perfusion imaging of hypervascular liver lesions performed over multiple breath-holds (BHs) requires compensation for motion between BH periods. In this work, we utilize a contrast-enhanced 3D radial acquisition with 4s true temporal footprint to image the entire abdomen of four healthy volunteers and four patients with hepatocellular carcinoma. We demonstrate that suspension of respiratory motion during sequential BHs produces images free of motion artifact, and that rigid registration of BH-averaged image volumes provides excellent correction for subject motion and variations in residual lung volume between BHs.

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Keywords

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