Meeting Banner
Abstract #1962

A Method for Correcting T1 Maps of Prostate at 3T Obtained by Variable Flip Angle Imaging

Sandeep N. Gupta1, Ehud J. Schmidt2, Robert Mulkern3, Andriy Fedorov2, Ileana Hancu1, Yingxuan Zhu1, Clare Tempany-Afdhal2, Fiona Fennessy2

1GE Global Research Center, Niskayuna, NY, United States; 2Radiology, Brigham and Women's Hospital, Boston, MA, United States; 3Radiology, Boston Children's Hospital, Boston, MA, United States

Dynamic Contrast Enhanced MRI has shown promise in non-invasive assessment of tumor vascular properties with applications in prostate cancer staging and treatment monitoring. Analysis of DCE requires knowledge of pre-contrast T1 maps. T1 mapping using Variable Flip Angle imaging is inaccurate due to B1 inhomogeneity. We present a simple approach for correcting VFA T1 maps by incorporating knowledge of approximate T1 of known reference tissue. This method can be used to produce clinically usable T1 maps in prostate. Our method was tested in 8 prostate patients and verified using a multiple-TR approach and the Bloch-Siegert B1 mapping method.

Keywords

accurate acquisition actual additional agent analyzed anatomic application applied approaches approved approximated approximates assessment assumed assumption available cancer children closely commonly computationally concentration conjunction consuming content contrast conversion correct corrected correcting correction coverage curves cycles degrees dependent determine determining differing dummy dynamic efficient enabling enhanced enveloping equation errors estimating estimations field fits generally gland global good health hence hospital identical inhomogeneities inhomogeneity institute institutes intensity invasive iteratively justified knowledge known linearly local made mapping maps matrix measured models monitoring muscle national necessarily official paper part patient patients pelvic pixel pixels preferred presence primary prior promise properties propose proposed prostate protocols published radiology reasonable related represent requires requiring resolution responsibility resultant routine scanned scanner several severe simple since slice solely spatial spatially spectral spin staging step strengths strongly subject subjects suffers support supported suppression tissue treatment tumor uncorrected uniform uptake useful utilizes validated variable vascular versus views volume weakly widely wise women