Meeting Banner
Abstract #1957

How the Spatial Distribution of the Vessels Affects T2*? a 2D Simulation Study.

Nicolas Pannetier1, 2, Clement Debacker, 13, Franck Mauconduit, 13, Christen Thomas4, Emmanuel Barbier, 13

1Grenoble Institut des Neurosciences, Universite Joseph Fourier, Grenoble, France; 2Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, United States; 3U836, INSERM, Grenoble, France; 4Department of Radiology, Stanford University, Stanford, CA, United States

We investigated how the spatial distribution of the vessels impacts the relaxation rate T2* of the MR signal. We used simulation in 2D with different constraints on the vessels distribution. We found that at 7T, the distribution of the vessels may impacts for about 8% the SO2 estimates. Moreover we found an interesting linear relationship between T2* and a spatial frequency that characterizes the distribution of the vessels.

Keywords

account achieve affects agreement analytical approaches arranged arrangement arrangements assumption assumptions authors automatic averaging better blood blue cells certain characteristic characterization christen clement closest coefficients computed connection considered constant constraint containing contrast counting created currently cutoff cylinders deal defines delivery density designed develop deviation diffusion distance distribution drug ease environment establishing eventually exponential expressed favored field finite fitted flow fluctuations forward free frequency function generated good green heterogeneous homemade idea impacts implementation in vivo index infinite initial instance isotropic known larger lead leads length limit linear linearly link locally located maps mechanisms might mimic model modeled models moreover norm orientation originated originating orthogonal pathologies perfusion phys plan plateau power proposed proven push quantified radiology radius random randomly regarding regression related relation relationship remain saturates sets several shorter simulation simulations since software spatial spectrum starts statistical step structure suggest susceptibility tends tissue tumor unconstrained uniform useful variations various vascular vessel vessels volume water years