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Abstract #1933

A HARDI Multi-Subject Bundle Atlas of Known Deep White Matter and Short Superficial White Matter Tracts

Pamela Guevara1, 2, Delphine Duclap1, 3, Cyril Poupon1, 3, Linda Marrakchi-Kacem, 14, Josselin Houenou1, 5, Marion Leboyer5, Denis Le Bihan1, Jean-Fraois Mangin1, 3

1Neurospin, CEA, Gif-sur-Yvette, France; 2University of Concepcin, Concepcin, Chile; 3IFR 49, Gif-sur-Yvette, France; 4UPMC, CRICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, ICM, Paris, France; 5AP-HP, Univ. Paris-East, Dept. of Psychiatry, INSERM, U955 Unit, France

We present a HARDI human brain multi-subject bundle atlas derived from a two-level intra-subject and inter-subject clustering strategy. Each atlas bundle corresponds to several inter-subject clusters labeled by an expert in neuroanatomy to account for subdivisions of the underlying pathway often presenting large variability across subjects. An atlas bundle is represented by the multi-subject list of the centroids of all intra-subject clusters in order to get a good sampling of the shape and localization variability. The atlas contains 36 bundles deep white matter bundles belonging to brain hemispheres and the corpus callosum, and 47 superficial white matter bundles in each hemisphere.

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Keywords

account additional affine aimed aims aligned amount anatomical artifacts association atlas atlases automatic belonging better brain bundle bundles called centroids cluster clustering clusters complete composed computed connections connectivity context corpus corrected corresponds dataset datasets decomposition deconvolution deep described description deterministic diffusion distance divided east efficient embedded embedding examples excite expert fascicles fiber fibers field good healthy hemisphere hemispheres human identify important improvements includes individual inference inferior inferred inter intra invasive jean kind known labeled labeling least length like local localization manually mask material measures million neuroanatomy normalization orientation pairwise parts pathway population powerful preceding preliminary previous produced propagation proposed providing psychiatry qualities quality radiations reconstructed reduces refocused regular regularization representation represented rigid sampling segmentation segmentations selected sensitivity several shape shapes short shot space spatial spherical spin spurious streamline structures studied studies subdivisions subject subjects superficial susceptibility system thalami thin think thousand tool tracts transform transformation twice underlying unit variability white whole