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Abstract #1857

Relating Diffusion Tensor MRI-Derived Alterations in Myocardial Microstructure to Reduced Wall Motion in Hypertensive Left Ventricular Hypertrophy

Archontis Giannakidis1, Alexander I. Veress2, Mustafa Janabi1, James P. O'Neil1, Osama M. Abdullah3, Edward W. Hsu3, Grant T. Gullberg1, 4

1Radiotracer Development and Imaging Technology, Lawrence Berkeley National Laboratory, Berkeley, CA, United States; 2Department of Mechanical Engineering, University of Washington, Seattle, WA, United States; 3Bioengineering, University of Utah, Salt Lake City, UT, United States; 4Radiology, University of California San Francisoc, San Francisco, CA, United States

DT-MRI delineation of microstructural alterations and temporal evolution of ventricular wall mechanics in hypertensive left ventricular hypertrophy.

Keywords

alterations analyzed animal animals assessing attributed bear bearing bioengineering called capability capable cardiac certain chest classic comparable compartment computation computed contract contractile control counterclockwise decreased deformation demand derived detecting diagnostic diastole diffusion direct disarray diseased diseases disorder distributions employed energy exhibited expressed extensive extreme fact fiber fibers finite fixation force formalin fractional function gates generally geometries health heart hearts helix horizontal hypertension hypertensive hypertrophy hypothesis index injected insight inter invasive laboratory laborious lake least lifetime light literature longitudinal loss made mass materials matrix measured mechanical metabolism microscopy model models modulating morphological much muscle myocardial myocardium nominal nonparametric normalized nuclear office opposed optimized orientation package partly placed plots powerful preparation presence principal progression properties rats reconstructed reduced reflecting regarding regular regularity relation reliable remodeling role rotation scanner separate significance spin stage start statistical stiffening strain streamline studies systole table take technology tensor together tool tracking upon ventricular wall warping whole younger zonal