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Abstract #1852

ADC Increase Following Radiotherapy Is a Proxy for Necrotic But Not Apoptotic Cell Death in LoVo Tumour Xenografts

MAGNA25Daniel Peter Burke1, Kaye Williams2, John Charles Waterton1, Muhammed Babur2, James O'Connor1

1Imaging Sciences, University of Manchester, Manchester, United Kingdom; 2School of Pharmacy, University of Manchester, Manchester, United Kingdom

 

Keywords

absolute acquisition aged anatomical animal animals assay assessed assuming axis background basis beam cancer cell cells chemotherapy clinical committee compliance computed contiguous control correlated correlation cryostat death decrease degradation degree design detects determined diffusion dominant early efficacy either ethical evidence examining excised external female findings fitting frozen greater growth guidelines harry histological histology hour hours hypothesis implanted induced initiated inst john kingdom lack least local maps matrix measured mechanism mice minute model mouse natl necrosis necrotic neither nick noise objective paired percentage percentages peter phantom pharmacy phys plotted positively post prepared procedures proceed proposed providing proxy radiotherapy rapidly reached reflect relate reported represent resin respectively response review scanner school sciences scientific sections several sham significance significantly slices snap solid spin squares stained staining statistical student studentship studies support supported tailed terminal therapy transceiver treated treatment unpaired useful validated validation volume water weeks welfare wise workman