Meeting Banner
Abstract #1826

1H-MRS Changes in the Rat Brain Due to Circadian Cycle

Serguei Liachenko1, Jaivijay Ramu1

1NCTR / FDA, Jefferson, AR, United States

Circadian clocks regulate many physiological processes in biological systems. The diurnal changes in these processes may result in different sensitivity to pharmacological intervention as well as to the toxicity. Current study investigated the diurnal differences in neurometabolic profiles of nave adult rats using proton MRS

Keywords

account activity agents among anesthetized animals anterior array awaken bird body brain cage central channel choline circadian coil comparing composition concentrations cycle days depending development disappeared diurnal drug dynamic effective especially evaluate extract fluctuations glutamate goal hour hours impact individual influenced invasive light maintained male many measured mechanisms metabolite metabolites nervous neural neurotransmitters nocturnal offset onset oxygen pharmacological physiological positioned press processes profiles proton rats receive regular related response rhythms scanning sensitivity shimming significantly software spectra spectroscopy spectrum starting statistical stimuli studies subjected suggest summed suppression system systemically systems take temperature together toxicity toxicological transmit underlying vapor variation variations various water