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Abstract #1823

Reduced Glucose Oxidation by Glutamatergic Neurons in Cerebral Cortex During Normal Aging in Mice

Anant Bahadur Patel1, Pandichelvam Veeraiah1, Mohammad Shameem1, Vivek Tiwari1

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

Changes in mitochondrial function at the cellular level is not fully understood under normal aging. Present study investigates glucose oxidation by glutamatergic and GABAergic neurons, and neurotransmitter cycling in adult and aged mice. Cortical glutamate level was found to be reduced in aged mice. The glucose oxidation by glutamatergic neurons was decreased in aged mice while GABAergic functions seems to be unperturbed.

Keywords

accumulation addition adult aged aging anesthesia anesthetized animal approved bath biology blood body brain cellular cerebral circulated cognitive committee concentration constant cortex cortical council course cycling decline decreased detailed determined diseases dissolve enrichment ethics extract extracted fasted fitting flow frozen fully function funding glucose glut glutamate head healthy heating implicated induction industrial infused infusion initial institute investigated label labeling least liquid loss maintained male materials measured memory metabolic metabolism metabolites mice modeling molecular months neurons neurotransmitter nitrogen nonlinear overnight oxidation percent plasma processes protocols recorded reduced regulated related required role scientific seems sensory significantly spectrometer spectroscopy spectrum squares studied suggested suggesting supported tail temperature tissue together unchanged understand understood urethane vein warmed water