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Abstract #1817

Proton T1 Relaxation Times of Metabolites in Human Occipital White Matter and Grey Matter at 7T

MAGNA25Lijing Xin1, Benoit Schaller2, Vladimir Mlynarik2, Huanxiang Lu3, Rolf Gruetter, 12

1Department of Radiology, University of Lausanne, Lausanne, Switzerland; 2Laboratory of functional and metabolic imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Institute of Surgical Technologies and Biomechanics, University of Bern, Switzerland

In this study, T1 relaxations of 1H resonances (singlets and J-coupled peaks) of brain metabolites in occipital white matter and grey matter were measured at 7T using an inversion recovery semi-adiabatic SPECIAL sequence. T1 values of metabolites ranged from 900-2100ms and those of GSH, scyllo-Ins, Tau and NAAG were determined for the first time. T1 of NAA, tCho, Glu and NAAG were significantly different in WM and GM. The reported values will be useful for the quantification of metabolites by MR spectroscopy at 7T.

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