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Abstract #1812

Is metabolic Connectivity Across Spared Non-Primary Motor Areas Altered in Stroke?

Carmen M. Cirstea1, 2, Hung-Wen Yeh1, 3, Anda E. Popescu1, Ali Bani-Ahmed1, 2, In-Young Choi1, 4, Phil Lee1, 5, Sorin Craciunas6, William M. Brooks1, 4

1Hoglund Brain Imaging Center, University of Kansas, Kansas City, KS, United States; 2Departments of Physical Therapy; 3Biostatistics; 4Neurology; 5Molecular & Integrative Physiology, University of Kansas, Kansas City, KS; 6Neurosurgery Unit IV, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Although metabolite abnormalities have been documented in survivors of stroke by magnetic resonance spectroscopy, the relationship between metabolites in discrete anatomic areas that form cognitive networks is less well understood. Our goals were to establish evidence of "metabolic connectivity" in normal brain and to determine whether such connectivity was altered in radiologically normal appearing cortex following a sub-cortical stroke.

Keywords

alteration alterations altered although among analyses anatomic appearing aspects assess bani biostatistics bootstrapping brain brooks canonical carol carried certain chronic city coefficients commonly concentrations confirmed connectivity consequently considerably contrast control controls corrected correlation correlations cortex cortices coupling dorsal elucidated especially evidence examine finding findings fraction function functional generally glutamate goal greater guided healthy hemisphere hemispheres hemispheric hung identify individual informative injury insights integrative integrity inter interactions intra involved involving longer magnitude many marker matched matrix medicine metabolic metabolite metabolites might mild molecular months motor neurology neuron neuronal neurosurgery nine overall parametric particularly patients pattern persist perturbed pharmacy physical physiology possibly post press previous primary proton putative quantify radiologically recently reflective regional relationships remain report reported several severe sided significantly since slice spared spectroscopy stroke strokes studies suggest suggests supplementary surprisingly survivors system table therapy tissue unilateral unit visible weaker weeks whether years young