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Abstract #1808

Brain Chemical Concentrations in Autism Spectrum Disorder at 6, 12 and 24 Months as Measured with Magnetic Resonance Spectroscopic Imaging

Neva M. Corrigan1, Mindy Olson2, Todd Richards1, Dennis WW Shaw, 12, Annette Estes3, 4, Stefan Posse5, Stephen R. Dager1, 3

1Radiology, University of Washington, Seattle, WA, United States; 2Seattle Children's Hospital, Seattle, WA, United States; 3Autism Center, University of Washington, Seattle, WA, United States; 4Speech and Hearing Sciences, University of Washington, Seattle, WA, United States; 5University of New Mexico, Albuquerque, NM, United States

Brain imaging research has demonstrated alterations in brain volume and chemistry in children with autism spectrum disorder (ASD) at 2-5 years of age. The mechanisms and time of onset of these abnormalities are unknown. Magnetic spectroscopy provides chemical information that may help elucidate the cellular mechanisms that lead to the observed structural alterations as well as abnormal behavioral features characteristic of this disorder. We present findings from 3D MR spectroscopic imaging of children at higher risk for developing of ASD at 6, 12 and 24 months of age and compare them to findings for children at lower risk for developing ASD.

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Keywords

abnormal acquisition additional analyzed arch attempts autism bands behavioral black brain cell cerebral channel characteristic characterization chemical child children choline circumference coil compartment comprising concentrations connection consistent consortium constitute correction cross crucial date decrease decreases degree density developing development diagnosed disorder earlier early elevations elucidate emergence enlarged enlargement exhibited extending family features findings fitting genetic glutamate gray growth head hearing help hospital ibis illustrated individual infant infants insight interpreted interval known life linear link lipid little longitudinal matrix measured mechanisms minimize month months natal neurology neuronal onset outer part partial pattern period pipeline positioning posse post preliminary processing prolonged proportionate psychiatry quantification radiology reduced reduction reflect regression relatively report resolution risk saturation scalp scanned scanner sedation shaw site slab slabs sleeping sparks spectra spectral spectroscopic spectrum speech stage steady structural studies subjects subsequently suggest suppressed symptoms temporal thereafter tissue trajectory trio types typically underlying utilized ventricles volume volumes water whereas years