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Abstract #1760

Age and Breast Density Dependence of Choline in Breasts of Healthy Female Subjects Found Using 3D-MRSI

SUMMA25Lenka Minarikova1, Wolfgang Bogner1, Marek Chmelik1, Katja Pinker-Domenig1, Hubert Bickel1, Thomas Helbich1, Siegfried Trattnig1, Stephan Gruber1

1Centre of Excellence HF MR, Department of Radiology, Medical University of Vienna, Vienna, Austria

In previous studies, using single-voxel MR-spectroscopy or mutlivoxel MR-spectroscopy imaging (MRSI), choline signal with higher SNR was defined as a marker of malignancy in breast lesions. We present that choline signal can be detected using MRSI with high SNR in a large fraction of normal breast tissue and the SNR demonstrates an exponential correlation with breast density and age of the subject. Therefore, breast MRS-data from younger subjects with breast lesions should be interpreted with caution.

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Keywords

account applied apply benign breast breasts cancer caution choline clinical coil comparable concentration containing correlation defined density dependence depending detectable detected determined diagnosis differentiation dimensional distinguish distribution encoding excellence exponential false female females filter finding foreknowledge fraction hamming healthy important indicate inside interpreted isotropic lesions likely malignancy malignant marker material measured medical motivated nelson noise outer patients pilot pinker positive press previous processed processing protocol proton radiology rare reduced regression relevance report reported resolution scheduled sensitivity several significantly software spatial specificity spectra spectral spectroscopic spectroscopy steps studies subject subjects successfully suppression system taken tissue tool trio vibe visible volume volunteers water weak women young younger zero