Meeting Banner
Abstract #1758

ProFit Revised

Alexander Fuchs1, Peter Boesiger, Anke Henning

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

ProFit, a previously developed fitting tool for 2D JRPRES spectra was revised and certain drawback of the original implementation were tackled. Measured 2D JPRESS macromolecular baseline signals, surface splines to handle residual baseline distortions and a 2D model-free lineshape based on regularized splines were incorporated into ProFit. The results were compared between the recent and the revised version and it is shown that the inclusion of the these additional features together with a fine-tuned handling of prior knowledge leads to significantly better fit results.

Abstract PDF

Keywords

achievable achieved additional another applied basis become brain called clearly column comes comp complex coup deconvolution degrees detection deviations dimension ding diseases distortions double drastically drawbacks duration engineering ether experiment final finally fitted fitting flexible free frequency fully glutamate handle handled healthy henning human identified impeded implemented improve improved in vivo included iterations knowledge last like many maxim measured metabolite metabolites model molecular molecule newly noise occur original overall overlap pared parent part peak peter plots possibilities previous prior problems produce profit projection proposed prov quality quantification real reconstructed reduce reduced regularized residual residuals revised sampled self sett shape sign significantly simulated software special spectra spectral spectrum spin spline splines spread starting still subplots system systems tackle tails tensor tilted together tool tuning vent version visible