Meeting Banner
Abstract #1756

Assessment of Automated Brain Region Directed 3D Proton Spectroscopy Data Analysis Pipeline

Jun Xu1, 2, John D. West1, Andrew J. Saykin1, Ulrike Dydak, 12

1Department of Radiology and Imaging Sciences, Indiana University School of Medcine, Indianapolis, IN, United States; 2school of Health Sciences, Purdue University, West Lafayette, IN, United States

An automated analysis of 3D MRSI data is being presented, which takes into account contributions from specific brain structures to each MRSI spectrum and thus allows obtaining brain region specific metabolite values. We demonstrate on the example of hippocampus data extracted from a 3D MRSI dataset that this type of brain-region specific analysis if more sensitive to small neurochemical changes occurring only in one brain structure, but not in adjacent ones, than current analysis methods. The method has been developed for an easy and sensitive comparison of metabolite levels of specific brain structures across groups in clinical studies.

Abstract PDF

Keywords

abnormal accomplished according account accurate acquisition acquisitions allow amount analyzed around array assessment authors brain challenge changing clinical coil comparing concentration concentrations confirm considering constructed containing controls correction correctness developed differ directed display draw effort enough equipped essential example fast field form formation fully head health hods human include indicated john listed make many mask masks massive mated matrix metabolite nominal normalized original overlay partial particular patient pipeline pipelines planning process proton purely rage readily registered registration resolution respectively scanner school sciences segmentation sensitive sensitivity simulate simulated simulation spectral spectroscopic spectrum statistical still structural structure student studies subject subjects subtle table thalamus thank tissue trio unit unweighted valuable view volume volumes want weigh west white