Meeting Banner
Abstract #1747

Correlation-Based Cross Validation of PRESS, MEGA PRESS Editing and 2D JPRESS at 3T

Ayse Sila Dokumaci1, Niklaus Zlch1, Michael Wyss1, Alexander Fuchs1, Peter Bsiger1, Anke Henning1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Neurotransmitters and antioxidants such as N-acetyl-aspartate (NAA), glutamate (Glu), glutamine (Gln), gamma-aminobutyric acid (GABA), and glutathione (GSH) play an important role in psychiatric pathophysiologies. Their detection in vivo can be performed by the dedicated 1H MRS methods such as PRESS using different echo times, MEGA-PRESS, and 2D JPRESS at 3T. However, the best method to be used is unknown. Therefore, in this work these methods were applied on 40 healthy volunteers and in 4 different brain regions for cross validation. PRESS sequence with the shortest echo time and JPRESS sequence were found to be the best candidates for this purpose.

Abstract PDF Poster PDF

Keywords

achieved acid almost ample analyzed anterior antioxidants applied bands behind best black blocks body brain chosen coil component concentration concentrations consent correlation correlations correspondence cortex coupled cross debate dedicated detect detection disorders duce editing elation enable enabled engineering ethics expected feasibility fitting glutamate good green head healthy hence highly hods in vivo increments individual informed inner invasive investigation known localized magenta make materials mega mentioned metabolite metabolites meters middle model offset ongoing pairs peter potential predictors pres press prior prof quality quantification quantified questions relation reliably reveal shim shimming short shortest sign since solved spacing spectra spectral spin stems suffered sufficient suppress suppression surprise systems table transmit validated validation vapor variance visual volume volunteers water whereas whole written