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Abstract #1745

GABA Editing Without Water Suppression

Roland Kreis1, Christine Sandra Bolliger1, Erin Leigh MacMillan1, Uwe Boettcher2, Chris Boesch1

1Depts Clinical Research and Radiology, University Bern, Bern, Switzerland; 2Healthcare Sector, Customer Solutions Division , Siemens AG, Erlangen, Germany

MEGA PRESS editing is the most widely used technique for GABA measurements in human brain. Because it is an add/subtract method and measurement times are long, it is susceptible to small frequency, phase and amplitude drifts due to either patient related or technical instabilities. We have therefore combined it with non-water-suppressed MRS using the metabolite cycling technique to include the strong water signal in every acquisition as a reference signal. Editing parameters were optimized In Vitro and in vivo for stability and sensitivity while retaining suppression efficiency for contaminating macromolecule signals.

Keywords

accurate achieved acquisitions addition adiabatic alignment altered alternating amplitude aqueous array artifacts brain broadening cancellation chemical chess clinical coedited coediting coil combination combined common comparing continuous control cooperative correction cortex coupling cycling deliberate dependence described division drastically drifts duration eddy edited editing experimental extra fitted fitting fluctuations foundation frequencies frequency full function glutamate hands head healthy henry ideally illustrated improved in vivo independent individually induced instabilities instable irregular kaiser knowledge larger lead leads loss macromolecular manufacturers meaningful measure mega metabolite motion movement much multiplet national occasional occipital offset optimizations optimized optimizing optimum original overall overlapping package particular partner peak penalty performance placed post press prevented processing product progress providing pulse pulses quantification radiology rather realignment reconstruct recorded refocusing related reliable retaining satellite scheme schemes science sector selective separates setting shape solution spectra spectrum step still stored subjects subtract sufficient suggested supported suppressed suppression susceptible swiss symmetric symmetrically though triplet upfield vitro water width