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Abstract #1734

Highly Accelerated Parallel 1H MRSI at 7T with Simultaneous Suppression of Near- And Far-Reaching Signal Leakage

Thomas Kirchner1, Ariane Fillmer1, Peter Boesiger1, Klaas Paul Pruessmann1, Anke Henning1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

We tailor the SENSE reconstruction algorithm towards accelerated parallel MRSI at ultra-high field strengths. Through calculation on an overdiscretized spatial grid and careful tuning of the spatial response function we achieve efficient suppression of signal contaminations caused by voxel bleeding without the increase of the effective voxel size that would be caused by conventional filtering techniques. We demonstrate up to 9-fold accelerated proton MRSI in vivo at 7T.

Keywords

accelerated acceleration acceptable account achieve achieved acquisition aliasing assessment assignments available basis best biomedical bleeding brain called causes coil combining compromise constraints contamination contributions correction cost cross decay decreases desired diagnosis direct effective efficient either employed ensuing even example excellent exhibits extend extremely favorable field find fold free function functions furthermore gain generally gives good grid half healthy henning highly identified importance improved incomplete indicating induction inherently insight introduced investigate leads leakage limitations lobe lobes long loss maintenance make matrix metabolite metabolites middle minimal minimization much newly noise nominal object optimization optimized outstanding parallel particularly peak peaks physiological presence previous processes quality quantification reaching real reconstructed reconstruction regularization reliable removing represented residual resolution response section selectively sense sensitivities sensitivity setting severe shape shim shimming side simulate since slice space spatial spatially spectra spectroscopic spectrum striking stronger studies subset suppression system target term theory threefold together tool typical unfolding variation water widening