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Abstract #1727

Localised 31P MRS with a Modified SPECIAL Pulse Sequence in Mouse Skeletal Muscle at 7T

Isabell K. Steinseifer1, Patrcia M. Nunes1, Marnix C. Maas1, Tom W.J. Scheenen1, 2, Andor Veltien1, Ralf Mekle3, Rolf Gruetter4, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Erwin L. Hahn Institute for Mgnetic Resonance Imaging, Essen, Germany; 3Physikalisch-Technische Bundesanstalt, Berlin, Germany; 4EPFL, Lausanne, Switzerland

We present localized 31P MRS with a modified SPECIAL sequence of a 125μl voxel inside mouse skeletal muscle at 7T. By implementing a GOIA-WURST(16,4) pulse we overcome RF inhomogeneities and increased chemical-shift artefacts in slice selective localization caused by high-magnetic field. With a comparable time resolution we were able to obtain a similar SNR as with an FID measurement of the whole mouse leg. Artefacts caused by signal contamination from neighbouring bones were eliminated because of good localisation. The short echo time allowed acquisition of J-modulated ATP signals. We reached sufficient time resolution to follow ischemia in selected muscles.

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Keywords

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